Yes, though to be fair, it's not what Simplero is designed for.
There are two things making it a bit cumbersome:
Simplero doesn't include logic to calculate the shipping cost, so it has to be included in the price.
Simplero doesn't have a fully released shopping cart. We currently have a feature in the testing stages. If you want to test it out, contact support.
Yes, you can. There are some things you need to take into account though:
If all of those constraints are ok with you, then you're good to go.